2018.04.26 澳大利亚昆士兰大学许志平教授

来源：null   发布时间： 2018-04-19  

报告题目：Clay Nanoparticles as Efficient Vaccine Adjuvants for Animal and Human Health

报告人：许志平 教授 （澳大利亚昆士兰大学）

报告时间：2018年4月26日 15:30-16:30 (星期四)

报告地点：生化工程科研楼一楼会议室

主持人：刘瑞田 研究员

报告人简介：许志平教授是澳大利亚昆士兰大学生物工程与纳米技术研究所教授/UQ VC高级研究员，1988年于中国科学技术大学应用化学系获得学士学位，1991年于新加坡国立大学环境化学工程系获得博士学位。研究兴趣集中在:粘土纳米材料的控制制备，及相关纳米技术在药物/基因递送治疗癌症及其他疾病，纳米佐剂提升人及动物健康，疾病组织（特别是肿瘤组织）的成像和诊断，作物保护和杂草生长控制等方面的应用。在各个国际知名期刊如Nature Plants, Advanced Materials, ACS Nano, Small等累计发表超过230篇文章，他人引用超过9000次，H因子大于50，RSC Advance副主编及六个国际期刊的编委。

报告内容简介：Pathogenic Escherichia coli, such as enterohemorrhagic E. coli (EHEC) and enteropathogenic E. coli (EPEC), are responsible for a series of human diseases worldwide, and vaccine offers a more efficient and feasible public intervention. As the key component of vaccine, adjuvant has been actively pursued, including various nanomaterials, to enhance the immunity against the bacteria. Recently, clay nanoparticles, i.e. layered double hydroxides (LDHs) and hectorite (HEC), appear as effective adjuvants with desirable physicochemical properties.

We investigated the vaccine formulations containing the essential infectious factor IB for EHEC and EPEC and clay nanoparticles. Both LDH and HEC nanoparticles are able to carry an appreciable amount of IB, and significantly facilitate the cellular internalization of IB. The medium size LDH (115 nm) and HEC (77 nm) both induced much stronger antibody and cell-mediated immune responses than those by commercial adjuvants, QuilA as well as Alum, and maintained much higher levels of specific antibody immune response for at least four months. Such immunization in mice showed a very strong immunity for the host cells against the target bacteria in the in vitro assays. We finally examined the possible mechanism for the immunity promotion using clay nanoparticles as the adjuvant, which has demonstrated that both clay nanoparticles with suitable size appear as very promising vaccine adjuvants for animal and human health.