马光辉课题组

Ma Guanghui  Ph. D.

课题组长、中国科学院院士、实验室主任、团队首席

日本东京工业大学获博士学位（1993年）

Email: ghma@ipe.ac.cn

研究领域

均一、可控可生物降解聚合物纳微球制备及其作为活性物质（蛋白质、多肽等）的包埋与可控释放研究

均一、可控可生物降解聚合物纳微球制备及其作为疫苗佐剂的应用与机理研究

智能型药物载体的设计与应用研究

生物分离用微球介质的制备与应用研究

发表的主要论文（近5年）

[1]Qi Liu, Xiaoming Chen, Jilei Jia, Weifeng Zhang, Tingyuan Yang, Lianyan Wang, Guanghui Ma. pH-Responsive Poly(D,L‑lactic-co-glycolicacid) Nanoparticles with Rapid Antigen Release Behavior Promote Immune Response, ACSNano, 2015, 9 (5): 4925-4938. (IF 13.774)
[2]Weifeng Zhang, Lianyan Wang, Tingyuan Yang, Yuan Liu, Xiaoming Chen, Qi Liu, Jilei Jia, Guanghui Ma. Immunopotentiator-loaded polymeric microparticles as robust adjuvant to improve vaccine efficacy, Pharmaceutical Research, 2015, 32(9): 2837-2850. (IF 4.723)
[3]Lianyan Wang, Tingyuan Yang, Guanghui Ma. Particle Design of Membrane Emulsification for Protein Drug and Vaccine Delivery, Current Pharmaceutical Design, 2015, 21 (19): 2563-2598. (IF 3.555)
[4]Lianyan Wang, Mingming Cai, Yuan Liu, Tingyuan Yang, Yejing Zeng, Yueling Zhang, Qiang Li, Baocheng Zhu, Guanghui Ma. Polymer hydrophobicity regulates paclitaxel distribution in microspheres, release profile and cytotoxicity in vitro, Powder Technology, 2015, 275: 77-84. (IF 2.499)
[5]Yufei Xia, Qingze Fan, Dongxia Hao, Jie Wu, Guanghui Ma, Zhiguo Su. Chitosan-based mucosal adjuvants: Sunrise on the ocean, Vaccine, 2015, 33(44), 5997-6010.
[6]Yifeng Sheng, Guanqing Sun, Jie Wu, Guanghui Ma, To Ngai. Silica-Based Liquid Marbles as Microreactors for the Silver Mirror Reaction, Angewandte Chemie, 2015, 54(24), 7012-7017.
[7]Jie Wu, Qingze Fan, Yufei Xia, Guanghui Ma. Uniform-sized particles in biomedical field prepared by membrane emulsification technique, Chemical Engineering Science, 2015, 125, 85-97.
[8]Jie Wu, YueQi Wang, Qing-Ze Fan, YouBin Wu, Guanghui Ma. Novel hydrogel adjuvant based on quaternized chitosan for H5N1 split vaccine, Journal of Controlled Release, 2015, 213, e51-e52.
[9]Feng Qi, Liuqing Yang, Jie Wu, Guanghui Ma, Zhiguo Su. Microcosmic Mechanism of Dication for Inhibiting Acylation of Acidic Peptide, Pharmaceutical Research, 2015, 32 (7), 2310-2317.
[10]Rongyue Zhang, Qiang Li, Yongdong Huang, Lan Zhao, Peili Ye, Guanghui Ma, Zhiguo Su. Preparation of PEGA grafted poly(chloromethylstyrene-co-ethylene glycol dimethacrylate) monolith for high-efficiency solid phase peptide synthesis under continuous flow techniques. Polymer, 2015, 61: 115-122.
[11]Chenxu Zhang, Rongyue Zhang, Qiang Li, Yongdong Huang, Lan Zhao, Zhiguo Su, Fangling Gong, Zheng Lv, Hongyan Song, Wei Li, Qipeng Yuan, Guanghui Ma. Rapid octreotide separation from synthetic peptide crude mixtures by chromatography on poly(styrene-co-divinylbenzene)-based reversed phases. Separation and Purification Technology, 2015, 154: 351-358.
[12]Rongyue Zhang, Qiang Li, Dekun Ji, Bo Xu, Yongdong Huang, Lan Zhao. Preparation of a novel polymer monolith with high loading capacity by grafting block poly(PEGA–mPEGA) for high-efficiency solid phase synthesis. Reactive and Functional Polymers. 2015, 94: 63-69.
[13]Xiunan Li, Yaqiong Li, Chao Chen, Dawei Zhao, Xiaojun Wang, Lan Zhao, Hong Shi, Zhiguo Su. Pore size analysis from low field NMR spin-spin relaxation measurements of porous microspheres. Journal of Porous Materials. 2015, 22: 11-20.
[14]Yu Lin, Yongdong Huang, Wei Zheng, Kui Wu, Qun Luo, Yao Zhao, Shaoxiang Xiong, Fuyi Wang. Quantification of bindings of organometallic ruthenium complexes to GSTπ by mass spectrometry. Journal of Inorganic Biochemistry. 2015, 146: 44-51.
[15]Yace Mi, Weiqing Zhou, Qiang Li, Fangling Gong, Rongyue Zhang, Guanghui Ma, Zhiguo Su. Preparation of water-in-oil emulsions using a hydrophobic polymer membrane with 3D bicontinuous skeleton structure. Journal of Membrane Science, 2015, 490: 113-119.
[16]Yace Mi, Weiqing Zhou, Qiang Li, Donglai Zhang, Rongyue Zhang, Guanghui Ma, Zhiguo Su. Detailed exploration of structure formation of an epoxy-based monolith with three-dimensional bicontinuous structure. RSC advances, 2015, 68:419-427.
[17]Lijing Sun, Zhidong Xiong, Weiqing Zhou, Ruina Liu, Xingran Yan, Juan Li, Wenqi An, Guoqiang Yuan, Guanghui Ma, Zhiguo Su. Novel konjac glucomannan microcarriers for anchorage-dependent animal cell culture. Biochemical Engineering Journal, 2015, 68: 419-427.
[18]Weichen Wang, Weiqing Zhou, Juan Li, Dongxia Hao, Zhiguo Su, Guanghui Ma. Comparison of covalent and physical immobilization of lipase in gigaporous polymeric microspheres. Bioprocess and Biosystems Engineering, 2015, 38(11), 2107-2115.
[19]Dezhi Ni, Hui Ding, Shan Liu, Hua Yue, Yali Bao, Zhenhua Wang, Zhiguo Su, Wei Wei, Guanghui Ma. Superior intratumoral penetration of paclitaxel nanodots strengthens tumor restriction and metastasis prevention. Small, 2015, 11, 2518-2526. (IF 8.416)
[20]Qiang Fu, Piping Lv, Zhongke Chen, Dezhi Ni, Lijun Zhang, Hua Yue, Zhanguo Yue, Wei Wei, Guanghui Ma. Programmed co-delivery of paclitaxel and doxorubicin boosted by camouflaging with erythrocyte membrane. Nanoscale, 2015, 7, 4020-4030. (IF 6.925)
[21]Hui Ding, Yanlin Lv, Dezhi Ni, Jie Wang, Zhiyuan Tian, Wei Wei, Guanghui Ma. Erythrocyte membrane-coated biomimetic nanovectors with programmed delivery and near-infrared light triggering properties for photodynamic therapy of cancer. Nanoscale, 2015, 7, 9806-9815.
[22]Hua Yue, Wei Wei, Zonglin Gu, Dezhi Ni, Nana Luo, Zaixing Yang, Lin Zhao, Jose-Antonio Garate, Ruhong Zhou, Zhiguo Su, Guanghui Ma. Exploration of graphene oxide as an intelligent platform for cancer vaccines. Nanoscale, 2015, 7, 19949-19957.
[23]Nana Luo, Dezhi Ni, Hua Yue, Wei Wei, Guanghui Ma. Surface-engineered graphene navigate divergent biological outcomes toward macrophages. ACS Applied Materals Interfaces, 2015, 7, 5239-5247.
[24]张博，王瑛，王启宝，杨婷媛，张贵锋，王连艳，快速膜乳化法制备尺寸均一的载硫酸亚铁明胶微球，过程工程学报，2015, 15: 847-853。
[25]刘雁南，王连艳，杨婷媛，刘艳辉，马光辉，白油佐剂粒径均一性与炎症和免疫学效应相关性，过程工程学报，2015, 15: 653-658。
[26]徐婧，王连艳，杨婷媛，刘艳辉，马光辉，聚乳酸纳米颗粒的制备与表征，过程工程学报，2015, 15: 495-500。
[27]何超群，杨婷媛，王连艳，张贵锋，齐峰，张嵘，马光辉，SD大鼠Ⅱ型糖尿病模型的建立与评价，过程工程学报，2015, 3: 501-505。
[28]刘艳，王月琦，范清泽，吴有斌，吴颉，马光辉，快速膜乳化法与热固化法制备粒径均一的pH敏感壳聚糖季铵盐凝胶微球，过程工程学报，2015, 15: 473-481。
[29]张静飞，赵岚，黄永东，张志刚，马光辉，苏志国，葡聚糖接枝型高载量金属螯合介质的制备与性能，过程工程学报，2015, 15: 111-118。
[31]Weifeng Zhang, Lianyan Wang, Yuan Liu, Xiaoming Chen, Qi Liu, Jilei Jia, Tingyuan Yang, Shaohui Qiu, Guanghui Ma. Immune responses to vaccines involving a combined antigen-nanoparticle mixture and nanoparticle-encapsulated antigen formulation. Biomaterials. 2014, 35(23): 6086-6097
[32]Xiaoming Chen, Yuying Liu, Lianyan Wang, Yuan Liu, Weifeng Zhang, Bei Fan, Xiaowei Ma, Qipeng Yuan, Guanghui Ma, Zhiguo Su. Enhanced humoral and cell-mediated immune responses generated by cationic polymer coated PLA microspheres with adsorbed HbsAg. Mol Pharm. 2014, 11(6): 1772-1784
[33]Lin Dai, Tingyuan Yang, Jing He, Lihong Deng, Jing Liu, Luying Wang, Jiandu Lei, Lianyan Wang. Cellulose-graft-poly(L-lactic acid) nanoparticles for efficient delivery of anti-cancer drugs. J Mater Chem B. 2014, 2: 6749-6757
[34]Weifeng Zhang, Lianyan Wang, Yuan Liu, Xiaoming Chen, Jiahui Li, Tingyuan Yang, Wenqi An, Xiaowei Ma, Ruowen Pan, Guanghui Ma. Comparison of PLA Microparticles and Alum as Adjuvants for H5N1 Influenza Split Vaccine: Adjuvanticity Evaluation and Preliminary Action Mode Analysis. Pharm Res. 2014, 31(4): 1015-1031
[35]Tongtong Ma, Lianyan Wang, Tingyuan Yang, Dong Wang , Guanghui Ma, Siling Wang. PLGA-lipid liposphere as a promising platform for oral delivery of proteins. Colloid Surface B. 2014, 117: 512-519
[36]Tongtong Ma, Lianyan Wang, Tingyuan Yang, Dong Wang , Guanghui Ma, Siling Wang. M-cell targeted polymeric lipid nanoparticles containing a toll-like receptor agonist to boost oral immunity. Int J Pharm. 2014, 473(1-2): 296-303
[37]Yuan Liu, Yu Zhang, Xiaoxiao Yang, Lianyan Wang, Guanghui Ma. Uniform-sized water-in-oil vaccine formulations enhance immune response against Newcastle disease and avian influenza in chickens. Int Immunopharm. 2014, 23(2): 603-608
[38]Xiaoming Chen, Lianyan Wang, Qi Liu, Jilei Jia, Yuan Liu, Weifeng Zhang, Guanghui Ma, Zhiguo Su. Polycation-decorated PLA microspheres induce robust immune responses via commonly used parenteral administration routes. Int Immunopharm. 2014, 23(2): 592-602
[39]Shaohui Qiu, Qiang Wei, Zhenlun Liang, Guanghui Ma, Lianyan Wang, Wenqi An, Xiaowei Ma, Xin Fang, Peng He, Hemin Li, Zhongyu Hu. Biodegradable polylactide microspheres enhance specific immune response induced by Hepatitis B surface antigen. Hum Vacc Immunother. 2014, 10(8): 2350-2356
[40]Yuying Liu, Xiaoming Chen, Lianyan Wang, Tingyuan Yang, Qipeng Yuan, Guanghui Ma. Surface charge of PLA microparticles in regulation of antigen loading, macrophage phagocytosis and activation, and immune effects in vitro. Particuology. 2014, 17: 74-80
[41]Yuan Liu, Guifeng Zhang, Lihong Deng, Jiandu Lei, Lianyan Wang, Jing He. Synthesis characterization and adsorption behavior of molecularly imprinted nanoparticles for tripterine using precipitation polymerization. Anal Methods-UK. 2014, 6(3): 684-689
[42]Habiba Nazir, Weifeng Zhang, Yuan Liu, Xiaoming Chen, Lianyan Wang, MM Nasee, Guanghui Ma. Silicone oil emulsions: strategies to improve their stability and applications in hair care products. International Journal of Cosmetic Science. 2014, 36(2): 124-133
[43]Tongtong Ma, Lianyan Wang, Tingyuan Yang, Dong Wang , Guanghui Ma, Siling Wang. Homogeneous PLGA-Lipid nanoparticle as a promising oral vaccine delivery system for ovalbumin. Asian J Pharm Sci. 2014, 9: 129 -136
[44]Wang Lianyan*, Liu,Yuan, Zhang Weifeng, Chen Xiaoming, Yang Tingyuan, and Ma Guanghui, Microspheres and microcapsules for protein delivery: strategies of drug activity retention, Current Pharmaceutical Design, 2013, 19(65): 6340-6352.
[45]Liu Yuan, Yin Ying, Wang Lianyan*, Zhang Weifeng, Chen Xiaoming, Yang Xiaoxiao, Xu Junjie*, and Ma Guanghui*, Surface hydrophobicity of microparticles modulates adjuvanticity, Journal of Materials Chemistry B, 2013, 1(32): 3888-3896.
[46]Liu Yuan, Yin Ying, Wang Lianyan, Zhang Weifeng, Chen Xiaoming, Yang Xiaoxiao, Xu Junjie*, and Ma Guanghui*, Engineering Biomaterial-Associated Complement Activation to Improve Vaccine Efficacy, Biomacromolecules, 2013, 14(9): 3321-3328.
[47]Li Qiang, Zhang Rongyue, Li Jua, Yan Xiaofeng, Wang Lianyan, Gong Fangling*, Su Zhiguo, and Ma Guanghui*, In situ inhibitor (HCl) removal promoted heterogeneous Friedel-Crafts reaction of polystyrene microsphere with Lewis acids catalysts, Journal of Molecular Catalysis A: Chemical, 2013, 37: 53-65.
[48]Wang Lianyan*, Yang Tingyuan, Yang Jian, Li Qiang, Hao Dongxia, Yang Juanjuan and Ma Guanghui*, In situ Magnetization Technique for Synthesis of Magnetic Polymer Microspheres, Powder Technology, 2013, 235(5): 1017-1024.
[49]Wang Yuxia, Qin Jia, Wei Yi, Li Chunping, Ma Guanghui*, Preparation strategies of thermo-sensitive P(NIPAM-co-AA) microspheres with narrow size distribution, Powder Technology, 2013, 236: 107-113.
[50]Yue Zhanguo, You Zuoxiang, Yang Qinzheng, Lv Piping, Yue Hua, Wang Bin, Ni Dezhi, Su Zhiguo, Wei Wei*, Ma Guanghui*, Molecular structure matters: PEG-b-PLA nanoparticles with hydrophilicity and deformability demonstrate their advantages for high-performance delivery of anti-cancer drugs, Journal of Materials Chemistry B, 2013, 1: 3239-3247.
[51]Yue Zhanguo, Lv Piping, Yue Hua, Gao Yongjun, Ma Ding, Wei Wei*, Ma Guanghui*, Inducible graphene oxide probe for high-specific tumor diagnosis, Chemical Communications, 2013, 49(37): 3902-3904.
[52]Wei Wei, Lv Piping, Chen Xiaoming, Yue Zhanguo, Fu Qiang, Liu Shiyin, Yue Hua, Ma Guanghui*, Codelivery of mTERT siRNA and paclitaxel by chitosan-based nanoparticles promoted synergistic tumor suppression, Biomaterials, 2013, 4(15):3912-3923.
[53]Liu Shiyin, Wei Wei, Yue Hua, Ni Dezhi, Yue Zhanguo, Wang Shuang, Fu Qiang, Wang YQ, Ma Guanghui*, Su Zhiguo*, Nanoparticles-based multi-adjuvant whole cell tumor vaccine for cancer immunotherapy, Biomaterials, 2013, 34(33):8291-8300.
[54]Ge Jun #; Lei Jiandu #; Zare RN. Protein-inorganic hybrid nanoflowers. Nature Nanotechnology, 2012, 7: 428-432. 共同第1作者(Equal contribution). (IF 33.781)
[55]Yue Hua, Wei Wei, Yue Zhanguo, Wang Bin, Luo Nana, Gao Yongjun, Ma Ding, Ma Guanghui, Su Zhiguo. The role of the lateral dimension of graphene oxide in the regulation of cellular responses. Biomaterials, 2012, 33(16): 4013-4021. (IF 8.415)
[56]Wu Youbin, Wei Wei, Zhou Meng, Wang Yueqi, Wu Jie, Ma Guanghui, Su Zhiguo. Thermal-sensitive hydrogel as adjuvant-free vaccine delivery system for H5N1 intranasal immunization. Biomaterials, 2012, 33: 2351-2360. (IF 8.415)
[57]Wei Yi, Wang Yuxia, Kang Aijun, Wang Wei, Ho Sa V, Gao Junfeng, Ma Guanghui, Su Zhiguo. A Novel sustained-release formulation of recombinant human growth hormone and its pharmacokinetic, pharmacodynamic and safety profiles. Molecular Pharmaceutics. 2012, 9: 2039-2048. (IF 5.634)
[58]Lv Pi-Ping, Ma Yu-Feng, Yu Rong, Yue Hua, Ni De-Zhi, Wei Wei, Ma Guang-Hui. Targeted delivery of insoluble cargo (paclitaxel) by pegylated chitosan nanoparticles grafted with Arg-Gly-Asp (RGD). Molecular Pharmaceutics, 2012, 9: 1736-1747. (IF 5.634)
[59]Hao Dong-Xia, Sandström Corine, Huang Yong-Dong, Kenne Lennart, Janson Jan-Christer, Ma Guang-Hui, Su Zhi-Guo. Residue-level elucidation of the ligand-induced protein binding on phenylargarose microspheres by NMR hydrogen/deuterium exchange technique. Soft Matter. 2012, 8 (23), 6248 - 6255. (IF 4.998)
[60]Wei Yi, Wang Yuxia, Wang Wei, Ho Sa V, Qi Feng, Ma Guanghui, Su Zhiguo. Microcosmic mechanisms for protein incomplete release and stability of various amphiphilic mPEG-PLA microspheres. Langmuir. 2012, 28: 13984-13992. (IF 4.514)
[61]Wu Youbin, Wu Shipo, Hou Lihua, Wei Wei, Su Zhiguo, Wu Jie, Chen Wei, Ma Guanghui. Novel thermal-sensitive hydrogel enhances both humoral and cell-mediated immune responses by mucosal vaccine delivery. European Journal of Pharmaceutics Biopharmaceutics, 2012, 81: 486-497. (IF: 4.406)
[62]Zhai Yanqin, Zhou Weiqing, Wei Wei, Qu Jianbo, Lei Jiandu, Su Zhiguo, Ma Guanghui. Functional gigaporous polystyrene microspheres facilitating separation of poly(ethylene glycol)-protein conjugate. Analytica Chimica Acta. 2012, 712(27): 152-161. (IF 4.144)
[63]Yue Hua, Wei Wei, Fan Bei, Yue Zhanguo, Wang Lianyan, Ma Guanghui, Su Zhiguo. The orchestration of cellular and humoral responses are facilitated by divergent intracellular antigen trafficking in nanoparticle-based therapeutic vaccine. Pharmacol. Res. 2012, 65: 189-197. (IF 3.875)
[64]Nazir Habiba, Wang Lianyan, Lian Guoping, Zhu Shiping, Zhang Yueling, Liu Yuan, Ma Guanghui. Multilayered silicone oil droplets of narrow size distribution: preparation and improved deposition on hair. Colloids and Surfaces B: Biointerfaces. 2012, 100: 42-49. (IF 3.354)
[65]Gao Fei, Ma Guanghui. Effects of microenvironment on supported enzymes. Topics in Catalysis, 2012, 55: 1114-1123. (IF 2.973)
[66]Zhang Rongyue, Li Qiang, Zhang Jin, Li Juan, Ma Guanghui, Su Zhiguo, Preparation of poly (ethylene glycol) acrylate grafted polystyrene resin for solid-phase peptide synthesis. Reactive and Functional Polymers,2012, 72: 773-780. (IF 2.727)
[67]Zhang Rongyue, Li Qiang, Li Juan, Zhou Weiqing, Ye Peili, Gao Yang, Ma Guanghui, Su Zhiguo. Covalently coating dextran on macroporous polyglycidyl methacrylate microsphere enabled rapid protein chromatographic separation. Materials Science and Engineering C, 2012, 32: 2628-2633. (IF2.423)
[68]Geng Liyuan, Kou Xin, Lei Jiandu, Su Haijia, Ma Guanghui, Su Zhiguo. Preparation, characterization and adsorption performance of molecularly imprinted microspheres for erythromycin using suspension polymerization. J Chem. Technol. Biotechnol. 2012, 87: 635-642. (IF 2.27)
[69]Na Xiangming, Gao Fei, Zhang Liye, Su Zhiguo, Ma Guanghui. Biodegradable microcapsules prepared by self-healing of porous microspheres. Macro Letters/ACS, 2012, 1: 697-700.
[70]Yueling Zhang, Wei Wei, Piping Lv, Lianyan Wang, Guanghui Ma. Preparation and evaluation of alginate-chitosan microspheres for oral delivery of insulin. European Journal of Pharmaceutics and Biopharmaceutics, 2011, 77(1): 11-19. (IF 4.4)
[71]Zhanguo Yue, Wei Wei, Zuoxiang You, Qinzheng Yang, Hua Yue, Zhiguo Su, and Guanghui Ma. Iron Oxide Nanotube for Magnetically Guided Delivery and pH Activated-Release of Insoluble Anticancer Drugs. Advanced Functional Materials, 2011, 21(18): 3446-3453.( IF 9.427) (Cover story)
[72]Ying Zhang, Fei Gao, Song-Ping Zhang, Zhi-Guo Su, Guang-Hui Ma, Ping Wang, Simultaneous production of 1,3-dihydroxyacetone and xylitol from glycerol and xylose using a nanoparticle-supported multi-enzyme system with in situ cofactor regeneration. Bioresource Technology, 2011, 102(2): 1837-1843. ( IF 4.901 )
[73]Zhanguo Yue, Wei Wei, Piping LV, Hua Yue, Lianyan Wang, Zhiguo Su, and Guanghui Ma. Surface Charge Affects Cellular Uptake and Intracellular Trafficking of Chitosan-based Nanoparticles. Biomacromolecules, 2011, 12 (7): 2440–2446. (IF 5.589)
[74]Yi Wei, Yuxia Wang Lianyan Wang, Dongxia Hao, Guanghui Ma. Fabrication strategy for amphiphilic microcapsules with narrow size distribution by premix membrane emulsification. Colloids and Surfaces B: Biointerfaces, 2011, 87: 399– 408.(IF 2.939)
[75]Yi Wei, Yu-Xia Wang, Wei Wang, Sa V. Ho, Wei Wei, Guang-Hui Ma. mPEG-PLA Microspheres with Narrow Size Distribution Increase the Controlled Release Effect of Recombinant Human Growth Hormone, Journal of Materials Chemistry, 2011, 21:12691–12699. (IF 5.441)
[76]Weiqing Zhou, Juan Li, Wei Wei, Zhiguo Su, Guanghui Ma. Effect of solubilization of surfactant aggregates on pore structure in gigaporous polymeric particles. Colloids and Surfaces A: Physicochem. Eng. Aspects. 2011, 384: 549–554. (IF 2.24)
[77]Jian-Bo Qu, Yong-Dong Huang, Guang-Lun Jing, Jian-Guo Liu, Wei-Qing Zhou, Hu Zhu, Jian-Ren Lu. A novel matrix derivatized from hydrophilic gigaporous polystyrene-based microspheres for high-speed immobilized-metal affinity chromatography. Journal of Chromatography B, 2011, 879: 1043–1048. (IF 3.0)
[78]Yueling Zhang, Xingyuan Jia, Lianyan Wang, Jingzhong Liu, and Guanghui Ma, Preparation of Ca-Alginate Microparticles and Its Application for Phenylketonuria Oral Therapy. Industrial﹠Engineering Chemistry Research, 2011, 50 (7): 4106-4112. (IF 1.758)
[79]Tianbao Si, Yuxia Wang, Wei Wei, Piping Lv, Guanghui Ma, Zhiguo Su. Effect of acrylic acid weight percentage on the pore size in poly(N-Isopropyl acrylamide-co-acrylic acid) microspheres. Reactive and Functional Polymers, 2011, 71(9): 728-735 (IF 2.63)
[80]Habiba Nazir , Piping Lv , Lianyan Wang , Guoping Lian, Shiping Zhu, Guanghui Ma. Uniform-sized silicone oil microemulsions: Preparation, investigation of stability and deposition on hair surface. Journal of Colloid and Interface Science, 2011, 364: 56–64 (IF 3.223)
[81]Pi-Ping Lv, Wei Wei, Hua Yue, Ting-Yuan Yang, Lian-Yan Wang, and Guang-Hui Ma. Porous Quaternized Chitosan Nanoparticles Containing Paclitaxel Nanocrystals Improved Therapeutic Efficacy in Non-Small-Cell Lung Cancer after Oral Administration. Biomacromolecules, 2011, 12: 4230–4239. (IF 5.589)
[82]Chan Wang, Piping Lv, WeiWei, Shengyang Tao, Tao Hu, Jingbang Yang and Chang gong Meng. A smart multifunctional nanocomposite for intracellular targeted drug delivery and self-release. Nanotechnology, 2011, 22: 415101. (IF 3.831) (Cover story)
[83]Lan Zhao，Yongdong Liu，Yongdong Huang， Xiunan Li，Yinjue Wang，Yan Li， Guanghui Ma，Zhiguo Su. Deliberate manipulation of the surface hydrophobicity of an adsorbent for an efficient purification of a giant molecule with multiple subunits. Journal of Separation Science, 2011, 34: 3186-3193. (IF 2.631)
[84]Liyuan Geng, Xing Kou, Jiandu Lei, Haijia Su, Guanghui Ma and Zhiguo Su. Preparation, characterization and adsorption performance of molecularly imprinted microspheres for erythromycin using suspension polymerization. Journal of Chemical Technology Biotechnology, 2011,DOI 10.1002/jctb.2757. (IF 1.817)
[85]Yanqin Zhai， Weiqing Zhou, Wei Wei, Jianbo Qu, Jiandu Lei, Zhiguo Su, Guanghui Ma. Functional gigaporous polystyrene microspheres facilitating separation of poly(ethylene glycol)–protein conjugate. Analytica Chimica Acta, doi:10.1016/j.aca.2011.11.004. (IF 4.309)
[86]寇 星, 耿立媛, 雷建都, 马光辉, 苏志国. 红霉素分子印迹聚合物纳米微球的制备及其吸附特性, 过程工程学报, 2011, 11(3): 481-486.

授权和申请发明专利（近5年）

[1]马光辉，苏志国，周炜清，卫强，超大孔聚合物微球及其制备方法，美国专利授权，授权号US 8,940,172，授权日2015.1.27
[2]马光辉，周炜清，康跻耀，张贵峰，苏志国，孙李靖，李娟，一种动物细胞培养用胶原蛋白覆层微载体及其制备方法，ZL201310099817.4
[3]马光辉，吴颉，赵希，苏志国，崔金梅，周炜清，一种双孔多糖微球及其制备方法、用途，ZL201310164999.9
[4]马光辉，周炜清，苏志国，陈娟，李娟，王伟宸，一种超大孔多糖微球及其制备方法，ZL201310024488.7
[5]王连艳，马光辉，刘婍，杨婷媛，周炜清，一种包埋抗原的胞内pH响应型聚乳酸类微球疫苗递送与佐剂系统及其制备方法，申请号：201510125835.4
[6]马光辉，吴颉，苏志国，田瑞，张洁. 粒径均一的多肽药物缓释微球或微囊制剂及制备方法. 中国发明专利，专利号：ZL200910084267.2
[7]雷建都，马光辉，苏志国，寇星，耿立媛. 一种尺寸均一的分子印迹聚合物纳微球制备方法及应用. 中国发明专利，专利号：ZL201010271478.X
[8]马光辉，赵希，吴颉，巩方玲，周炜清，苏志国. 一种分级式控温型膜乳化器. 中国发明专利，专利号：ZL201110278837.9
[9]马光辉，周炜清，苏志国，王佳兴，熊志冬，林丰凯. 一种尺寸均一的魔芋葡甘聚糖微球及其制备方法. 中国发明专利，专利号：ZL201110387111.9
[10]郝冬霞，马光辉，周炜清，巩方玲，苏志国. 一种具有广谱和持久自发荧光的聚合物微球及其制备方法. 中国发明专利，专利号：ZL201210230382.8
[11]马光辉，张荣月，李娟，周炜清，苏志国. 聚丙烯酸酯类及其共聚物材料亲水改性产品及其亲水改性方法. 中国发明专利，专利号：ZL201210091582.X
[12]马光辉，吕丕平，魏炜，王连艳，周炜清，苏志国. 一种装载难溶性药物的壳聚糖-壳聚糖衍生物纳米球、制备方法及其作为口服制剂的应用. 中国发明专利，专利号：ZL201210154138.8
[13]马光辉，韦祎，王玉霞，苏志国，周炜清. 重组人生长激素rhGH长效缓释微囊及其制备方法. 中国发明专利，专利号：ZL201010251521.6
[14]雷建都，马光辉，苏志国，耿立媛，寇星. 一种尺寸均一的分子印迹聚合物微球制备方法及应用. 中国发明专利，专利号：ZL201010271470.3
[15]马光辉，张荣月，苏志国，周炜清，李娟. 聚丙烯酸酯类或其共聚物亲水改性的方法及其产品和用途. 中国发明专利，专利号：ZL 201210183929.3
[16]马光辉，周炜清，康跻耀，张贵锋，苏志国，孙李靖，李娟. 一种动物细胞培养用胶原蛋白覆层微载体及其制备方法. ZL 201310099817.
[17]马光辉,苏志国,周炜清,卫强, 超大孔聚合物微球及其制备方法. EP2088160B1（欧洲授权）
[18]巩方玲,马光辉,苏志国, 用于制备纳米级-数十微米级乳液的膜组件以及乳液制备方法. 中国发明专利,ZL201010259838.4.
[19]马光辉,韦祎,王玉霞,苏志国,周炜清, 一种用于药物载体的多孔微球、制备方法及药物负载方法.中国发明专利，ZL201110164346.1.
[20]马光辉，周青竹，苏志国. 一种琼脂糖凝胶微球及其制备方法，中国发明专利，ZL 200710098700.9
[21]马光辉，曲剑波，苏志国，卫强. 一种表面亲水改性聚苯乙烯材料的方法及产品，中国发明专利，ZL200710177704.6
[22]马光辉，王连艳，苏志国，吕丕平，魏炜，卫强，张岳玲. 壳聚糖纳微球产品及其制备方法，中国发明专利，ZL 200810222635.0
[23]马光辉，巩方玲，苏志国. 一种膜乳化器以及乳液制备方法，中国发明专利，ZL 200810223283.0
[24]马光辉，高飞，王平，张颖，苏志国. 一种中空多孔微胶囊及其制备方法，中国发明专利，ZL 200810223586.2
[25]马光辉，赵永江，苏志国，翟艳琴，张磊. 一种以硫代磺酸酯为端基的聚烷基醚聚合物及合成和用途，中国发明专利，ZL 200810224633.

学术书著作章节（近5年）

[1] Jie Wu, Xi Zhao, Yueqi Wang, Guanghui Ma, Biomedical application of soft nano-/microparticles, Nano/Micro Science and Technology in Biorheology: Principles, Methods, and Applications, 261-294, Springer Verlag, Japan, 2015, Editors: Rio Kita, Toshiaki Dobashi, (Publication Date: 2015/7/14, ISBN: 4431548858 ).