闫学海课题组

Yan Xuehai  Ph. D.

课题组长、研究员

中科院化学所获博士学位（2008年）

Email: yanxh@ipe.ac.cn

研究领域

肽、蛋白质等生物分子的自组装和超分子作用机理，分子间多种弱相互作用的协同与调控多尺度分级有序组装和功能调控，构建仿生功能体系和原细胞（protocell）模型

纳微生物反应器的设计和组装，作为药物载体和剂型、疫苗佐剂、生物催化剂以及光动力治疗新材料和新技术

发表的主要论文（近5年）

[1] Kai Liu, Ruirui Xing, Chengjun Chen, Guizhi Shen, Linyin Yan, Qianli Zou, Guanghui Ma, H. Möhwald, Xuehai Yan. Peptide-induced hierarchical long-range order and photocatalytic activity of porphyrin self-assemblies. Angewandte Chemie International Edition, 2015, 54: 500-505.
[2] Qianli Zou, Kai Liu, M. Abbas, Xuehai Yan. Peptide-modulated self-assembly of chromophores towards biomimetic light-harvesting nanoarchitectonics, Advanced Materials, doi: 10.1002/adma.201502454.
[3] Chengjun Chen, Kai Liu, Junbai Li, Xuehai Yan. Functional architectures based on self-assembly of bio-inspired dipeptides: structure modulation and its photoelectronic applications, Advances in Colloid and Interface Science. 2015, 225: 177-193.
[4] Ruirui Xing, Tifeng Jiao, Linyin Yan, Guanghui Ma, Junbai Li, H. Möhwald, Xuehai Yan. Colloidal gold–collagen protein core–shell nanoconjugate: one-step biomimetic synthesis, layer-by-layer assembled film, and controlled cell growth, ACS Applied Materials Interfaces, 2015, 7: 24733-24740.
[5] He. Zhang, Jinbo Fei, Xuehai Yan, Anhe. Wang, Junbai Li. Enzyme-responsive release of doxorubicin from monodisperse dipeptide-based nanocarriers for highly efficient cancer treatment in vitro, Advance Functional Materials, 2015, 25: 1193-1204.
[6] Ruirui Xing, Tifeng Jiao, Qianli Zou, Xuehai Yan. Photothermally-induced molecular assembly of macroscopic peptide-inorganic hybrid films, Science of Advanced Materials, 2015, 7: 1701-1707.
[7] Tifeng Jiao, Yijia Wang, Qiri Zhang, Xuehai Yan, Xin Zhao. Organogels via gemini amphiphile-graphene oxide nanocomposites: self-Assembly and symmetry effect, Science of Advanced Materials, 2015, 7: 1677-1685.
[8] Chao Zhou, Manzar Abbas, Min Zhang, Qianli Zou, Guizhi Shen, Chengjun Chen, Hongshang Peng, Xuehai Yan. One-step nanoengineering of hydrophobic photosensitive drugs for the photodynamic therapy, Journal of Nanoscience and Nanotechnology, 2015, 15: 10141-10148.
[9]Qianli Zou, Lu Zhang, Xuehai Yan, Anhe Wang, Guanghui Ma, Junbai Li, H. Möhwald, S. Mann. Multi-functional Porous Microspheres Based on Peptide-Porpyhrin Hierarchical Co-assembly. Angew. Chem. Int. Ed. 2014, 53: 2366-2370
[10]Fenfang Zhao, Guizhi Shen, Chengjun Chen, Ruirui Xing, Qianli Zou, Guanghui Ma, Xuehai Yan. Nanoengineering of Stimuli-Responsive Protein-Based Biomimetic Protocells as Versatile Drug Delivery Tools. Chem. Eur. J. 2014, 20: 6880-6887 (Frontispiece).
[11]Tifang Jiao, Yujin Wang, Qingrui. Zhang, Xuehai Yan, Xiaoqing Zhao, Jingxin Zhou, Faming Gao. Self-Assembly and Headgroup Effect in Nanostructured Organogels via Cationic Amphiphile-Graphene Oxide Composites. PLoS One . 2014, 9: e101620
[12]Hongqiang Wang, Xuehai Yan, Guoling Li, C. Pilz-Allen, H. Möhwald, D. Shchukin. Sono-Assembly of Highly Biocompatible Polysaccharide Capsules for Hydrophobic Drug Delivery. Adv. Healthc. Mater. 2014, 3:825-831

授权和申请发明专利（近5年）

[1] 闫学海，邢蕊蕊，邹千里，陈成军，刘凯，马光辉，一种含纳米金的胶原凝胶及其制备方法和用途，申请号：2015101250846
[2] 闫学海，邹千里，刘凯，一种光敏剂纳米粒及其制备方法和用途，申请号：2015103732862
[3] 闫学海，陈成军，李淑坤，张宁，马光辉，一种低分子量肝素缓释制剂及其制备方法和应用，申请号：2015103595244
[4]闫学海，沈桂芝，陈成军，邹千里，马光辉. 一种基于络合包覆的药物纳米粒制剂及制备方法和用途. 中国发明专利，专利号：ZL201410140885
[5]闫学海，邹千里，马光辉，赵芬芳，陈成军，戴五敏. 一种基于白蛋白的纳米粒子、其制备方法及用途，中国，专利号：201310456200