张欣课题组

张欣 研究员 

学历/学位: 研究生学历/博士学位

研究方向: 核酸药物剂型工程

邮箱: xzhang@ipe.ac.cn

地址: 北京市海淀区中关村北二街1号

邮编: 100190

简历介绍：

张欣，研究员，博士生导师，2022年获得国家杰出青年科学基金，2015年获得国家优秀青年科学基金，现任生化工程国家重点实验室副主任。天津大学获得学士、硕士学位，法国斯特拉斯堡大学获得博士学位，法国国家健康与医学研究院任助理研究员，2010年任职于中科院过程工程研究所。长期聚焦制约核酸药物治疗成败的关键科学与工程技术问题，发表IF>10的SCI论文30余篇，申请专利20余项（授权12项）。现任Theranostics编委、Bioactive Materials编委、中国生物物理学会纳米生物学分会理事、中国生物材料学会青年委员会委员等。2018年获颁中国生物材料学会“青年科学家奖”，2020年获得上海市科学技术奖一等奖，2021年获得北京市自然科学二等奖。 

课题组主页：http://www.zhangxinlab.cn/

代表论著：

1. Jie Shen#, Zhiguo Lu#, Jianze Wang, Qiulian Hao, Weihong Ji, Yanyue Wu, Huan Peng, Ruichen Zhao, Jun Yang, Yan Li, Zhuyan Shi, Xin Zhang*. Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment. Advanced Materials, 2021, 33, 27, 2101993. （IF 32.0938）

2. Weihong Ji#, Yan Li#, Huan Peng, Ruichen Zhao, Jie Shen, Yanyue Wu, Jianze Wang, Qiulian Hao, Zhiguo Lu, Jun Yang, Xin Zhang*. Self-catalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases. Advanced Materials, 2021, 34, 1, 2105711.（IF 32.0938）

3. Chenmeng Qiao#, Jun Yang#, Qi Shen, Ruiyuan Liu, Yanhui Li, Yuanjie Shi, Jingli Chen, Yanqin Shen, Zuobing Xiao, Jie Weng*, Xin Zhang*. Traceable Nanoparticles with Dual Targeting and ROS Response for RNAi-Based Immunochemotherapy of Intracranial Glioblastoma Treatment. Advanced Materials, 2018, 18, 30,1705054.（IF 32.0938）

4. Ran Zhang#, Yan Li#, Bingbing Hu, Zhiguo Lu, Jinchao Zhang*, Xin Zhang*. Traceable Nanoparticle Delivery of Small Interfering RNA and Retinoic Acid with Temporally Release Ability to Control Neural Stem Cell Differentiation for Alzheimer's Disease Therapy. Advanced Materials, 2016, 28, 30, 634. （IF 32.0938）

5. Heng Deng#, Fengying Dai#, Guanghui Ma, Xin Zhang*. Theranostic Gold Nanomicelles made from Biocompatible Comb-like Polymers for Thermochemotherapy and Multifunctional Imaging with Rapid Clearance. Advanced Materials, 2015, 27, 24, 3645. （IF 32.0938）

6. Binging Hu#, Fengying Dai#, Zhanming Fan, Guanghui Ma, Qunwei Tang*, Xin Zhang*. Nanotheranostics: Congo Red/Rutin-MNPs with Enhanced Magnetic Resonance Imaging and H2O2-Responsive Therapy of Alzheimer’s Disease in APPswe/PS1dE9 Transgenic Mice. Advanced Materials, 2015, 27, 37, 5499. （IF 32.0938）

7. Weihong Ji#, Yan Li#, Huan Peng, Ruichen Zhao, Xin Zhang*. Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases. Advanced Drug Delivery Reviews, 2022, 180,114029. （IF 21.6523）

8. Yan Li#, Linying Liu#, Weihong Ji#, Huan Peng, Ruichen Zhao, Xin Zhang*. Strategies and materials of “SMART” non-viral vectors: Overcoming the barriers for brain gene therapy. Nano Today, 2020, 35,101006. （IF 20.2393）

9. Zhiguo Lu#, Yan Li#, Yuanjie Shi, Yanhui Li, Zuobing Xiao, Xin Zhang*. Traceable Nanoparticles with Spatiotemporally Controlled Release Ability for 5 Synergistic Glioblastoma Multiforme Treatment. Advanced Functional Materials, 2017, 46, 27,1703967. （IF 19.9775）

10. Yan Li, Yanhui Li, Weihong Ji, Zhiguo Lu, Linying Liu, Yuanjie Shi, Guanghui Ma, Xin Zhang*. Positively Charged Polyprodrug Amphiphiles with Enhanced Drug Loading and Reactive Oxygen Species-Responsive Release Ability for Traceable Synergistic Therapy. JACS, 2018, 140,11, 4164. （IF 16.289）