9月16号讲座 Encapsulation and Release: From Materials Science to Biosciences

来源：null   发布时间： 2013-09-12  

演讲嘉宾： Helmuth Möhwald Professor and director of MPIKG

演讲主持： 闫学海 研究员

演讲时间： 2013年9月16日（星期一）10:00-11:00（提前十分钟入场完毕）

演讲地点： 过程大厦223会议室

主 办： 人事教育处 综合办公室 生物大分子过程工程团队

嘉宾简介：

　　Prof. Helmuth Möhwald received his Diploma in Physics in 1971 at the University of Gottingen, Germany, and his PhD degree in 1974 at the Max Planck Institute of Biophysical Chemistry, Gottingen. After a postdoc at IBM and habilitation at the University of Ulm, he became C3 professor at the Technical University of Munich (1981). From a chair (C4) in physical chemistry at Univ. Mainz (1987) he became the founding director of the Max Planck Institute of Colloids and Interfaces in Potsdam (1993). He has received a lot of awards and honors from the world institutions. For example, among his recent awards were the Overbeek Medal of the European Colloid and Interface Society (2007), an Honorary Doctorate of the University of Montpellier, France (2008), the Wolfgang-Ostwald-Medal of the German Kolloid-Gesellschaft (2009), the BP Visiting Lecturer of Cambridge University, UK (2010) and the Member of the Academy of Europe (2012). His main research interests include biomimetic systems, capsules and controlled release, chemistry and physics in confined spaces, dynamics at interfaces, membrane biophysics and supramolecular interactions. He has more than 910 publications, which have been cited more than 38000 times. His h-index is 96, “Highly Cited Scientist”.

报告简介：

　　Alternating electrostatic assembly of oppositely charged polyelectrolytes has been shown to be a versatile technique to form stable multifunctional films. Since this technique does not depend on a planar support it has also been possible to coat sacrificial colloidal templates. After their removal hollow capsules were obtained with walls controlled as well as the planar films. These capsules on one hand promise many applications carriers for drugs or anticorrosion agents.

　　Inserting metallic nanoparticles into the walls of these capsules one can locally melt by IR light thus effecting release of drugs like signal peptides inside cells. Their function can then be followed microscopically. Another application in biosciences concerns films into which lipid/polyelectrolyte capsules have been inserted. Locally heating via nanoparticles as efficient IR absorbers one thus releases drugs affecting cells attached to the surface.

　　As the mechanical properties can be controlled at will one may tune them to induce mechanically the capsule release. This in turn can be converted into a pressure gauge estimating the pressure experienced by a capsule inside a cell.

　　One of the prominent applications of capsules in films results from the possibility that this can affect neighbouring cells via release upon a specific stimulus or via an external field. One example to be discussed will be antifungal coatings where a neighbouring bacterium excretes lactic acid that in turn causes a coating to reject the bacterium or causes release of a fungicide.