2017.08.28香港中文大学李泉教授

来源：null   发布时间： 2017-08-28  

Developing self-decomposable nanoparticle carriers for therapeutic applications and beyond
报 告 人：Prof. Quan Li, 香港中文大学
报告时间：2017年8月28日（星期一）15:00-16:00
报告地点：304会议室
主 办：无机功能材料课题组

报告人简介： Quan Li received her Bsc degree in Chemistry in 1997 from Peking University, and her PhD degree in 2001 in Material Science and Engineering, Northwestern University. In 2002, she joined Physics department, the Chinese University of Hong Kong, as assistant professor, and was promoted to associate professor and full professor in 2007, and 2011, respectively. Her research interests are functional nanostructure fabrication and characterizations of individual nanomaterials. In recent years, she devoted herself into multidisciplinary research topics including quantum sensing, biomedicine, and energy storage materials. She has been PI for 3 national projects, 2 international projects, and 19 Hong Kong projects. She has more than 200 peer-reviewed publications (citation >7000). Her H index is 45.
报告简介：An ideal nanoparticle (NP) carrier-drug system requires effective cellular uptake, controllable release, and safe excretion from the biological system after functioning. In the present talk, I will discuss our design of SiO2 based self decomposable nanoparticles as effective drug carriers for cancer therapeutics. A co-growth mechanism of drug and the carrier materials allows the inside out diffusion of drug molecules (drug release), leading to the self-decomposition of the nanoparticles simultaneously. This enables effective drug release from the carrier as well as easy renal clearance of the carrier materials after drug release. We show that by employing different loading schemes of the drugs, one can manipulate the drug release profiles in many different ways. Here I will give examples including sustained release of the drug at cellular level serving as effect strategy to bypass the multidrug resistance effect in cancer cells, and programmable multidrug release for significantly enhanced drug efficacy. Potential development of the drug carrier systems beyond therapeutic applications will also be discussed.