胡涛课题组

Hu Tao  Ph. D. 

课题组长、研究员

中国科学院过程工程研究所获博士学位（2003年）

Email: thu@ipe.ac.cn

研究领域

蛋白质药物的基因工程改造与PEG化学修饰

蛋白质药物的化学偶联

细菌荚膜多糖结合疫苗的研究

基于化学修饰的结核分枝杆菌亚单位疫苗

发表的主要论文（近5年）

[1] Mengfang Xu, Xueqing Xing, Zhonghua Wu, Yuguang Du, Tao Hu.   Molecular shape and immunogenicity of meningococcal polysaccharide group   A conjugate vaccine. Vaccine, 2015, 33: 5815-5821.
[2] Tingting   Zhang, Weili Yu, Yanfei Wang, Tao Hu. Moderate PEGylation of the carrier   protein improves the polysaccharide-specific immunogenicity of   meningococcal group A polysaccharide conjugate vaccine. Vaccine, 2015,   33: 3208-3214.
[3] Wenlin Qiao, Shaoyang Ji, Yubao Zhao, Tao Hu.   Conjugation of-glucan markedly increase the immunogencity of   meningococcal group Y polysaccharide conjugate vaccine. Vaccine, 2015,   33: 2066-2072.
[4] Ling Wu, Shaoyang Ji, Tao Hu. N-terminal   modification with pseudo bifunctional PEG-hexadecane markedly improves   the pharmacological profile of human growth hormone. Molecular   Pharmaceutics, 2015, 12: 1402-1411.
[5] Qingqing Wang, Tao Hu,   Shaoyang Ji, Guanghui Ma, Zhiguo Su. CO binding improves the structural,   functional, physical and anti-oxidation properties of the PEGylated   hemoglobin. Artificial Cells, Nanomedicine, and Biotechnology, 2015, 43:   18-25. 
[6]Ling Wu, Shaoyang Ji, Lijuan Shen, Tao Hu. Phenyl   amide linker improves the pharmacokinetics and pharmacodynamics of   N-terminally mono-PEGylated human growth hormone. Molecular   Pharmaceutics 2014, 11: 3080-3089
[7]Weili Yu, Changming Yu, Ling   Wu, Ting Fang, Rui Qiu, Jinlong Zhang, Ting Yu, Ling Fu, Wei Chen, Tao   Hu. PEGylated recombinant human interferon-ß as a long-acting antiviral   agent: Structure, antiviral activity and pharmacokinetics. Antiviral   Research 2014, 108: 142-147 
[8]Xiaoying Xue, Shaoyang Ji, Qimeng   Mu, Tao Hu. Heat treatment increases the bioactivity of C-terminally   PEGylated staphylokinase. Process Biochemistry 2014, 49: 1092-1096
[9]Qingqing   Wang, Lijing Sun, Shaoyang Ji, Dawei Zhao, Jiaxin Liu, Zhiguo Su, Tao   Hu. Reversible protection of Cys-93(β) by PEG alters the structural and   functional properties of the PEGylated hemoglobin. Biochim Biophys Acta   2014, 1844: 1201-1207
[10]Huang Qingrui, Li Dongxia, Kang Aijun,   An Wenqi, Fan Bei, Ma Xiaowei, Ma Guanghui, Su Zhiguo, Hu Tao*. PEG as a   spacer arm markedly increases the immunogenicity of meningococcal group   Y polysaccharide conjugate vaccine. Journal of Controlled Release 2013,   172: 382-389
[11]Wu Dinglong, Ji Shaoyang, Hu Tao*. Development of pneumococcal polysaccharide conjugate vaccine with long spacer arm.   Vaccine 2013, 31: 5623-5626
[12]Wu Ling， Sa V. Ho，Wang Wei，Gao   Jianping，Zhang Guifeng，Su Zhiguo，Hu Tao*. N-terminal mono-PEGylation of growth hormone antagonist: correlation of PEG size and pharmacodynamic   behavior. International Journal of Pharmaceutics 2013, 453: 533-540
[13]Mu   Qimeng, Hu Tao*, Yu Jingkai*.Molecular insight into the steric   shielding effect of PEG on the conjugated staphylokinase: biochemical   characterization and molecular dynamics simulation. PLoS One 2013, 8:   e68559
[14]Xue Xiaoying, Li Dongxia, Yu Jingkai, Ma Guanghui, Su   Zhiguo, Hu Tao*. Phenyl linker-induced dense PEG conformation improves   the efficacy of C-terminally monoPEGylated staphylokinase.   Biomacromolecules 2013, 14: 331-341 
[15]Hu Tao, Li Dongxia, Wang   Jun, Wang Qingqing, Liang Yangui, Su Yanlei, Ma Guanghui, Su Zhiguo,   Wang Shihua. Propylbenzmethylation at Val-1 markedly increases the   tetramer stability of the PEGylated hemoglobin: a comparison with   propylation at Val-1. Biochim Biophys Acta General Subjects. 2012,   1820: 2044-2051. (IF: 3.883)
[16]Li Chunju, Lin Qixun, Wang Jun,   Shen Lijuan, Ma Guanghui, Su Zhiguo, Hu Tao. Preparation, structural   analysis and bioactivity of ribonuclease A-albumin conjugate:   tetra-conjugation or PEG as the linker. Journal of Biotechnology. 2012,   162: 283-288. (IF: 3.288)
[17]Liu Shenxiang, Sun Lijing, Wang Jun,   Ma Guanghui, Su Zhiguo, Hu Tao. Mono-PEGylation of ribonuclease A: high   PEGylation efficiency by thiolation with small molecular weight   reagent. Process Biochemistry 2012, 47: 1364-1370. (IF: 3.225)
[18]Liu   Ruyan, Li Dongxia, Wang Jun, Qiu Rui, Lin Qixun, Zhang Guifeng, Ma   Guanghui, Su Zhiguo, Hu Tao. Preparation, characterization and in vitro   bioactivity of N-terminally PEGylated staphylokinase dimers. Process   Biochemistry. 2012, 47: 41-46. (IF: 3.225)
[19] Wang J, Hu T*, Liu   Y, Zhang G, Ma G, Su Z. Kinetic and stoichiometric analysis of the   modification process for N-terminal PEGylation of staphylokinase.   Analytical Biochemistry, 2011, 412: 114-116.

授权发明专利（近5年）

[1]胡涛，吴玲，苏志国，马光辉. 一种定点修饰N-末端的聚乙二醇化生长激素拮抗剂及其制备方法. 中国发明专利，专利号： ZL201310047046.4
[2]胡涛、安文琪、苏志国、范蓓、吴鼎龙、马小伟、潘若文，一种基于点击化学的肺炎多糖结合疫苗及其制备方法. ZL 201310047502.5
[3]胡涛，苏志国，马光辉，刘如艳. 重组葡激酶二聚体的制备及聚乙二醇定点修饰. 中国发明专利，ZL201110092374.7