刘瑞田课题组

刘瑞田，研究员、博士生导师，中国科学院过程工程研究所生物药物工程研究部主任，课题组长。长期从事治疗重大疾病的生物技术药物的研究。目前主要致力于神经退行性疾病发病机理及治疗阿尔茨海默病（老年性痴呆）、帕金森病和肿瘤等的基因工程抗体、疫苗、多肽及纳米药物的研究。为国家“十二五”、“十三五”重大新药创制专项责任专家，“蛋白质机器及生命调控”重点专项总体组专家，曾担任J Alzheimers Dis副主编、Adv Biosci & Biotech编委。先后主持国家重大科技专项、国家863、中科院先导专项和国家自然基金等10余项国家级科研项目。已在Nano Today、 Adv Func Mater、Neurobiol Dis、Alzheimers Res Ther和Br J Pharmacol等国际著名期刊发表论文80多篇，申请或获得国内外专利22项，2种一类新药处于中试研究中。

电子邮件：rtliu@ipe.ac.cn

发表的主要论文（近5年）

1. Ling-xiao Zhang; Xia-mei Sun; Ying-bo Jia; Xiao-ge Liu; Mingdong Dong; Zhi Ping Xu*; Rui-tian Liu*; Nanovaccine’s rapid induction of anti-tumor immunity significantly improves malignant cancer immunotherapy, Nano Today, 2020, 35, 100923.

2. Lun Zhang; Xiao-ge Liu; Shuai Lu; Dong-qun Liu; Xiao-lin Yu; Ling-xiao Zhang; Jie Zhu; Rui-tian Liu*; A conditionally releasable “don’t eat me” CD47 signal facilitates microglia-targeted drug delivery for the treatment of Alzheimer's disease, Advanced Functional Materials, 2020, 30 (18): 1910691.

3. Mei Ji; Jie Zhu; Xi-Xiu Xie; Dong-Qun Liu; Bin Wang; Zhuo Yu; Rui-tian Liu*; A novel rapid modularized hepatitis B core virus-like particle-based platform for personalized cancer vaccine preparation via fixed-point coupling, Nanomedicine, 2020, 28:102223.

4. Dong-Qun Liu; Shuai Lu; Lun Zhang; Ya-Ru Huang; Mei Ji; Xiao-Ying Sun; Xiao-Ge Liu; Rui-tian Liu*; Yeast-Based Aβ1-15 Vaccine Elicits Strong Immunogenicity and Attenuates Neuropathology and Cognitive Deficits in Alzheimer's Disease Transgenic Mice, Vaccines (Basel), 2020, 8(3):E351.

5. Mei ji^#; Xi-xiu Xie^#; Dong-qun Liu; Shuai Lu; Ling-xiao Zhang; Ya-ru Huang; Rui-tian Liu*; Engineered Hepatitis B Core Virus-Like Particle Carrier for Precise and Personalized Alzheimer’s disease Vaccine Preparation via Fixed-point Coupling, Applied Materials Today, 2020, 19:100575. 

6. Xiao-Lin Yu; Jie Zhu; Xiang-meng Liu; Peng-xin Xu; Yue Zhang; Rui-tian Liu*; Vaccines targeting the primary amino acid sequence and conformational epitope of Aβ had distinct effects on neuropathology and cognitive deficits in EAE/AD mice, British Journal of Pharmacology, 2020, 177, 2860-2871.

7. Xiao-Ge Liu; Lun Zhang; Shuai Lu; Dong-Qun Liu; Ling-Xiao Zhang; Xiao-Lin Yu; Rui-tian Liu*; Multifunctional Superparamagnetic Iron Oxide Nanoparticles Conjugated with Aβ Oligomer-Specific scFv Antibody and Class A Scavenger Receptor Activator Show Early Diagnostic Potentials for Alzheimer’s Disease, International Journal of Nanomedicine, 2020,15: 4919-4932.

8. Ling-xiao Zhang; Xia-mei Sun; Zhi Ping Xu*; Rui-tian Liu*; Development of Multifunctional Clay-Based Nanomedicine for Elimination of Primary Invasive Breast Cancer and Prevention of Its Lung Metastasis and Distant Inoculation, ACS Applied Materials & Interfaces, 2019, 11(39):35566-35576.

9. Ya-ru Huang^#; Xi-xiu Xie^#; Mei ji; Xiao-lin Yu; Jie Zhu; Ling-xiao Zhang; Xiao-ge Liu; Chen Wei; Gang Li*; Rui-tian Liu*; Naturally occurring autoantibodies against alpha-synuclein rescues memory and motor deficits and attenuates alpha-synuclein pathology in mouse model of Parkinson's disease, Neurobiology of Disease, 2019, 124: 202-217.

10. Xiao-ying Sun; Quan-xiu Dong; Jie Zhu; Xun Sun; Li-fan Zhang; Mandy Qiu; Xiao-lin Yu*; Rui-tian Liu*; Resveratrol rescues tau-induced cognitive deficits and neuropathology in a mouse model of tauopathy, Current Alzheimer Research, 2019, 16(8):710-722.

11. Quan-xiu Dong; Jie Zhu; Shu-ying Liu; Xiao-lin Yu*; Rui-tian Liu*; An oligomer-specific antibody improved motor function and attenuated neuropathology in the SOD1-G93A transgenic mouse model of ALS, International Immunopharmacology, 2018, 65: 413-421.

12. Dong-qun Liu^#; Shuai Lu^#; Ling-xiao Zhang; Mei Ji; Shu-ying Liu; Shao-wei Wang; Rui-tian Liu^*. An indoleamine 2, 3-dioxygenase siRNA nanoparticle-coated and Trp2-displayed recombinant yeast vaccine inhibits melanoma tumor growth in mice, Journal of Controlled Release, 2018, 273: 1-12.

13. Ling-xiao Zhang; Xi-xiu Xie; Dong-qun Liu; Zhi Ping Xu^*; Rui-tian Liu^*; Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy, Biomaterials, 2018, 174: 54-66.

14. Mei Ji^#; Xi-xiu Xie^#; Dong-qun Liu; Xiao-lin Yu; Yue Zhang; Ling-xiao Zhang; Shao-wei Wang; Ya-ru Huang; Rui-tian Liu*; Hepatitis B core VLP-based mis-disordered tau vaccine elicits strong immune response and alleviates cognitive deficits and neuropathology progression in Tau.P301S mouse model of Alzheimer's disease and frontotemporal dementia, Alzheimers Research & Therapy, 2018, 10(1): 0-55.

15. Shao-wei Wang^#; Dong-qun Liu^#; Ling-xiao Zhang^#; Mei Ji; Yang-xin Zhang; Quan-xiu Dong; Shu-ying Liu; Xi-xiu Xie; Rui-tian Liu^*; A vaccine with Aβ oligomer-specific mimotope attenuates cognitive deficits and brain pathologies in transgenic mice with Alzheimer’s disease, Alzheimers Research & Therapy, 2017, 9:41-54.

16. Ling-xiao Zhang^#; Dong-qun Liu^#; Shao-wei Wang^#; Xiao-lin Yu; Mei Ji; Xi-xiu Xie; Shu-ying Liu; Rui-tian Liu^*; MgAl-layered double hydroxide nanoparticles co-delivering siIDO and Trp2 peptide electively reduce IDO expression and induce cytotoxic T-lymphocyte responses against melanoma tumor in mice, Journal of Materials Chemistry B, 2017, 5, 6266-6276.

17. Jun Zha^#; Xiang-meng Liu^#; Jie Zhu^#; Shu-ying Liu; Shuai Lu; Peng-xin Xu; Xiao-lin Yu*; Rui-tian Liu*; A scFv antibody targeting common oligomeric epitope has potential for treating several amyloidosis, Scientific Reports, 2016, 6: 36631-36631.

18. Teng Wang^#; Xi-xiu Xie^#; Mei Ji^#; Shao-wei Wang; Jun Zha; Wei-wei Zhou; Xiao-lin Yu; Chen Wei; Shan Ma; Zhi-ying Xi; Guang-li Pang^*; Rui-tian Liu^*; Naturally occurring autoantibodies against Aβ oligomers exhibited more beneficial effects in the treatment of transgenic mice with Alzheimer’s disease than intravenous immunoglobulin, Neuropharmacology, 2016, 105:561-576. 

授权和申请发明专利（近5年）

1. 刘瑞田，季梅，谢喜秀，疫苗通用载体及其制备方法和应用，2019.11.29，中国，申请号：201911205559.7

2. 刘瑞田，谢喜秀，季梅，一种重组蛋白及其制备方法和应用，2018.1.25，中国，申请号：201810072365.3

3. 刘瑞田，刘小歌，于晓琳，卢帅，一种具有寡聚体特异性的核磁造影剂及其制备方法与应用，2018.10.25，中国，申请号：201811248832.X

4. 刘瑞田，黄亚茹，谢喜秀，一种天然α-syn寡聚体抗体的制备方法及其产品和应用，2018.11.23，中国，申请号：201811238751.1

5. 刘瑞田，张凌宵，一种纳米颗粒及其制备方法和应用，2017.1.10，中国，申请号：201710014816.3

6. 刘瑞田，王少伟，章杨新，一种多肽及其组成的疫苗和应用，2017.5.12，中国，申请号：201710333187.0

7. 刘瑞田，于晓琳，朱杰，一种结合多种淀粉样蛋白单体和聚集体的多肽及其应用，国际PCT专利申请号：PCT/CN2016/106585

8. 刘瑞田，于晓琳，张燃，苏雅静，查君，一种结合多种淀粉样蛋白单体和聚集体的多肽及其应用，2015.11.25，中国，申请号：201510831563.X

9. 刘瑞田，于晓琳，查君，一种多肽及其应用，2015.11.30，中国，申请号：201510856645.X